A novel regeneration therapyof the chronic stage cerebral ischemia with porous gelatin scaffold

本实验观察了大鼠短暂性脑缺血后神经修复和神经再生因子表达的变化，这对慢性期脑缺血的再生治疗具有重要意义。免疫组化和western blot分析表明，自由基清除剂依达拉奉可增加结直肠癌中轴突生长抑制蛋白neurocan、Sema 3A和Nogo-R的表达，并促进蛋白deleted的表达。本研究表明，这些蛋白质因子改善了缺血后脑修复中的这种损伤。

Changes in expression of neurorepair and neuroregenerative factors, which were important for the regeneration therapy of the chronic stage cerebral ischemia, were examined after transient rat cerebral ischemia. Immunohistochemistry and western blot analyses indicated that axonal growth inhibiting protein expression of neurocan, Sema3A, Nogo-R, and promoting protein expression of deleted in colorectal cancer was increased with edaravone, which was one of the free radical scavenger. The present study demonstrates that these protein factors ameliorated such damage inbrain repair after ischemia.