Roles of a novel lepin-induced transcript in the regulation of obesity and leptin resistance.

在正常和高脂饮食条件下，LIT2缺陷小鼠的体重比WT小鼠减轻，尽管WT和LIT2缺陷小鼠之间的摄食量没有变化。此外，与WT小鼠相比，LIT2缺陷小鼠的葡萄糖耐量和胰岛素敏感性都有所提高。这些结果表明，LIT2调节瘦素的活动，如能量消耗和葡萄糖代谢，而不是调节下丘脑的食物摄入。

In both normal and high-fat diet conditions, the body weights were decreased in LIT2-deficient mice compared to those in WT mice, although there were no changes in food intake between WT and LIT2-deficient mice. In addition, glucose tolerance and insulin sensitivity were increased in LIT2-deficient mice compared to those in WT mice. These results suggest that LIT2 regulates the actions of leptin such as energy expenditure and glucose metabolism rather than food intake in the hypothalamus.