Comparative effectiveness research in first-line therapies for untreated multiple myeloma

目前可用于治疗未经治疗的多发性骨髓瘤的一线治疗方法包括常规化疗、大剂量化疗后自体干细胞移植和基于新型药物的治疗，这些治疗方法是根据重要的临床因素如年龄、生化、细胞遗传学和分子标记进行选择的。我们进行了系统回顾和荟萃分析，以评估这些治疗策略的比较疗效，并对预后因素的证据进行了批判性评估。

Currently available first-line therapies for untreated multiple myeloma consist of conventional chemotherapies, high-dose chemotherapies followed by autologous stem-cell transplantation, and novel agents-based therapies, which are selected on the basis of important clinical factors such as age, and biochemical, cytogenetic, and molecular markers. We performed systematic reviews and meta-analyses to evaluate comparative efficacy of these therapeutic strategies, and critically appraised the evidence on the prognostic factors.