Regulation of autoreactive B cells in an anti-DNA antibody- knock-in mouse model

仅抑制自身反应性淋巴细胞的疗法对于系统性红斑狼疮（SLE）的治疗是期望的。我们分析了SLE模型“抗DNA抗体敲入小鼠”，以了解自身反应性B细胞是如何调节的。纯合子脾B细胞明显减少，骨髓中B细胞成熟受到抑制。人类的B细胞倾向于移动到脾脏的边缘区。人B细胞IgM/IgD表达水平较低，推测其受无反应性调节。进一步的分析将阐明SLE的病理生理学。

A therapy that inhibits only autoreactive lymphocytes is desirable for the treatment of systemic lupus erythematosus (SLE). We analyzed an SLE model ‘anti-DNA-antibody-knock-in mouse' to know how autoreactive B cells are regulated. The homozygotes' splenic B cells were significantly decreased, and their maturation was inhibited in the bone marrow. Homo's B cells tended to move to the marginal zone in their spleens. Homo's B cells showed low expression levels of IgM/IgD, and were supposed to be regulated by anergy. Further analyses will elucidate the pathophysiology of SLE.