Regulation of autoreactive B cells in an anti-DNA antibody- knock-in mouse model

一种仅抑制自身反应性淋巴细胞的治疗方法是治疗系统性红斑狼疮（SLE）的理想方法。我们分析了SLE模型“抗dna抗体敲入小鼠”，以了解自身反应性B细胞是如何被调节的。纯合子脾脏B细胞明显减少，骨髓成熟受到抑制。人属的B细胞倾向于向脾脏的边缘区域移动。人属B细胞IgM/IgD表达水平较低，被认为受能量调节。进一步的分析将阐明SLE的病理生理学。

A therapy that inhibits only autoreactive lymphocytes is desirable for the treatment of systemic lupus erythematosus (SLE). We analyzed an SLE model ‘anti-DNA-antibody-knock-in mouse' to know how autoreactive B cells are regulated. The homozygotes' splenic B cells were significantly decreased, and their maturation was inhibited in the bone marrow. Homo's B cells tended to move to the marginal zone in their spleens. Homo's B cells showed low expression levels of IgM/IgD, and were supposed to be regulated by anergy. Further analyses will elucidate the pathophysiology of SLE.