A role of Fc receptor beta-chain in the onset of arthritis elicited by anti-type II collagen antibodies
A role of Fc receptor beta-chain in the onset of arthritis elicited by anti-type II collagen antibodies
批准号:
23791124
负责人:
OHTSUBO Mino
金额:
$2.66万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Young Scientists (B)
财政年份:
2011
资助国家:
日本
项目状态:
已结题
起止时间:
2011 至 2012
中文摘要
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英文摘要
Fc receptor β chain (FcRβ) acts as a signaling component of FcγRIII in immune cells such as mast cells (MCs) or basophils. Recent studies reported that FcγRIII contributes to the development of arthritic inflammation. These findings suggest that FcRβ may play pivotal role in the pathogenesis of arthritic inflammation. To address this possibility, we examined the function of FcRβ in arthritic inflammation employing a mouse model. Our findings indicate that the FcRβ negatively regulatesFcγRIII-mediated MC activation and arthritic inflammation in experimental model.
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The role of Fc receptor in contact hypersensitivity
Fc受体在接触性超敏反应中的作用
DOI:
--
发表时间:
2012
期刊:
影响因子:
--
作者:
[Mino Ohtsubo-Yoshioka, Satoshi Nunomura, Chisei Ra.]
通讯作者:
Chisei Ra.
A novel resource for mast cell research: Common Marmoset MastCells
肥大细胞研究的新资源:普通狨猴肥大细胞
DOI:
--
发表时间:
2011
期刊:
影响因子:
--
作者:
[Satoshi Nunomura, Yoshie Kametani, Shin Shimada, Mino Yoshioka, Hiroshi Suemizu, Erika Sasaki, Chisei Ra.]
通讯作者:
Chisei Ra.
Fc receptor beta chain deficiency exacerbates murine arthritis in the anti-type II collagen antibody-induced experimental model.
在抗 II 型胶原抗体诱导的实验模型中,Fc 受体 β 链缺陷会加剧小鼠关节炎。
DOI:
10.1007/s10165-012-0749-z
发表时间:
2013
期刊:
Mod Rheumatol.
影响因子:
--
作者:
[Ohtsubo-Yoshioka M, Nunomura S, Kataoka TR, Okayama Y, Ra C.]
通讯作者:
Ra C.
接触過敏症におけるFc receptorの機能解析
Fc受体在接触性超敏反应中的功能分析
DOI:
--
发表时间:
期刊:
影响因子:
--
作者:
[織谷健司, 金倉譲, 大坪美乃]
通讯作者:
大坪美乃
Fc receptor beta-chain deficiency exacerbates arthritis in anti-type II collagen antibody induced-experimental mouse model
Fc 受体 β 链缺陷会加剧抗 II 型胶原抗体诱导的实验小鼠模型中的关节炎
DOI:
--
发表时间:
2011
期刊:
影响因子:
--
作者:
[Yoshioka Mino, Nunomura Satoshi, Kataoka Tatsuki, Okayama Yoshimichi, Ra Chisei]
通讯作者:
Ra Chisei
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