Developing a novel therapy with bone marrow mononuclear cells for perinatal brain injuries

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It is urgent to develop novel therapies for infants with perinatal hypoxic-ischemic encephalopathy (HIE). In the present project, we have performed basic experiments to develop a novel therapy with bone marrow mononuclear cells (BM-MNC), which is most ideal source of stem cells for the treatment against perinatal brain injuries. We evaluated the effect of administration of BM-MNC on perinatal HIE rat. We injected BM-MNC intravenously after hypoxic-ischemic insult. The injected BM-MNC was detected in the lung less than when we administered bone marrow mesenchymal stem cells. BM-MNC administration exerted anti-apoptotic effect, and tended to ameliorate learning impairment induced by HIE.