Genetic analysis of patent ductus arteriosus in preterm infants.

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Patent ductus arteriosus is a common morbidity associated with preterm birth. Our major goal was to determine if genetic risk factors play a role in patient ductus arteriosus seen in preterm infants. DNA samples collected from 80 infants with a gestational age less than 32 weeks. There were 41 boys and 39 girls. Mean gestational age was 29 weeks (22-31 weeks), mean birth weight was 1059g (476-2158g). Natural close of ductus arteriosus was seen in 30% in infants, indomethacin with one time was used in 46% in infants, and indomethacin with two times were used in 23% in infants. Surgical closure of ductus arteriosus was proceeded in 7% in infants. We investigated single nucleotide polymorphism in transcription factor AP-2 by real time polymerase chain reaction.