Establishment in evaluating antitumor immunity of inactivated HVJ-Eto malignant melanoma

灭活HVJ-Eto恶性黑色素瘤抗肿瘤免疫评价的建立

• 批准号: 23791268
• 负责人: TANEMURA Atsushi
• 金额: $ 2.66万
• 依托单位: Osaka University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011 至 2012
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23791268/
• 关键词: Hemagglutinating Virus of Japan-Envelope; 悪性黒色腫; 抗腫瘍免疫; 不活化センダイウイルスベクター; 不活化センダイウイルス

We evaluated the inducible humoral and cellular immunity of inactivated HVJ-E in the patients with advanced malignant melanoma. As results, we detected a novel and specific auto-antibody which was upregulated with HVJ-E administration in human as well as in melanoma cells bearing mice. CD4^+/ CD8^+T cells and CD11c^+dendritic cells robustly infiltrated particularly into the shrinking melanoma tissues, indicating that HVJ-E could augment the comprehensive anti-tumor immunity in malignant melanoma.

我们评估了灭活HVJ-E在晚期恶性黑色素瘤患者中诱导的体液和细胞免疫。作为结果，我们检测到一种新的和特异性的自身抗体，其在人类以及携带黑色素瘤细胞的小鼠中随着HVJ-E施用而上调。CD 4 ^+/CD 8 ^+T细胞和CD 11 c ^+树突状细胞在缩小的黑色素瘤组织中大量浸润，表明HVJ-E可增强恶性黑色素瘤的综合抗肿瘤免疫。

项目成果

Recent Advance and Development in Antitumor Effect of HVJ Envelope Vector in Malignant Melanoma; from Bench to Clinical Application

HVJ包膜载体抗恶性黑色素瘤作用的最新进展

• 发表时间: 2013
• 期刊: Cancer Gene Therapy
• 影响因子: 6.4
• 作者: Shigeru Matsumura;Mayumi Hamasaki;Takuya Yamamoto;Miki Ebisuya;Mizuho Sato;Eisuke Nishida;Fumiko Toyoshima;Atsushi Tanemura
• 通讯作者: Atsushi Tanemura

A Clinical Study Using the Hemagglutinating Virus of Japan-Envelope on Patients with Progressive Malignant Melanoma

日本信封血凝病毒治疗进展性恶性黑色素瘤的临床研究

• 发表时间: 2013
• 作者: Hayashi M;Suzuki T;Atsushi Tanemura
• 通讯作者: Atsushi Tanemura