The effects of skin tumor microenvironment on dendritic cellmediated immune response

皮肤肿瘤微环境对树突状细胞介导的免疫反应的影响

• 批准号: 23791276
• 负责人: NAKAHARA Takeshi
• 金额: $ 2万
• 依托单位: Kyushu University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011 至 2012
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23791276/
• 关键词: 樹状細胞; 悪性黒色腫; 腫瘍免疫

We examined phenotypic analysis of tumor-infiltrating dendritic cell (TIDC) at different time points after tumor injection. Murine melanoma were infiltrated by many conventional DC especially at early time point. Other dendritic cell subsets like plasmacytoid DC and CD11c+, B220+, Gr-1-, NK1.1+ DC were also infiltrating into the tumor although their proportion was very low. TIDC were a little more mature than lymphoid resident DCs in dLNs.From these results, we found that there were much more TIDC than expected at early stage of tumor growth, and detailed analysis of functions of these TIDC might be able to lead the new approach for enhancement of tumor immunity.

我们在肿瘤注射后的不同时间点检查了肿瘤浸润树突状细胞（TIDC）的表型分析。小鼠黑色素瘤中有大量的DC浸润，尤其是在早期。其他树突状细胞亚群如浆细胞样DC和CD 11 c+、B220+、Gr-1-、NK 1.1 + DC也有浸润，但比例很低。TIDC在dLN中的成熟度略高于淋巴驻留DC，提示在肿瘤生长早期TIDC的数量比预期的要多，详细分析TIDC的功能可能为增强肿瘤免疫提供新的途径。

项目成果

九州大学医学部皮膚科学教室

九州大学医学部皮肤科

Expression of c-Kit, p-ERK and cyclin D1 in malignant melanoma: An immunohistochemical study and analysis of prognostic value

• DOI: 10.1016/j.jdermsci.2011.02.011
• 发表时间: 2011-05-01
• 期刊: JOURNAL OF DERMATOLOGICAL SCIENCE
• 影响因子: 4.6
• 作者: Oba, Junna;Nakahara, Takeshi;Furue, Masutaka
• 通讯作者: Furue, Masutaka

The prognostic value of a reverse transcriptase-PCR assay of sentinel lymph node biopsy for patients with cutaneous melanoma: a single-center analysis in Japan

• DOI: 10.1097/cmr.0b013e32834dcfdf
• 发表时间: 2012-02-01
• 期刊: MELANOMA RESEARCH
• 影响因子: 2.2
• 作者: Ito, Takamichi;Moroi, Yoichi;Furue, Masutaka
• 通讯作者: Furue, Masutaka