The effects of skin tumor microenvironment on dendritic cellmediated immune response

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We examined phenotypic analysis of tumor-infiltrating dendritic cell (TIDC) at different time points after tumor injection. Murine melanoma were infiltrated by many conventional DC especially at early time point. Other dendritic cell subsets like plasmacytoid DC and CD11c+, B220+, Gr-1-, NK1.1+ DC were also infiltrating into the tumor although their proportion was very low. TIDC were a little more mature than lymphoid resident DCs in dLNs.From these results, we found that there were much more TIDC than expected at early stage of tumor growth, and detailed analysis of functions of these TIDC might be able to lead the new approach for enhancement of tumor immunity.