Role of ubiquitin-preteasome system in the immune-complex disease

为了评估泛素-前泌体系统在免疫复合物疾病中的作用，我们研究了野生型小鼠在有或没有硼替佐米蛋白酶体抑制的情况下皮肤Arthus反应。与未治疗的小鼠相比，硼替佐米治疗的野生型小鼠免疫复合物攻击引起的水肿和出血明显减少。与未处理的小鼠相比，硼替佐米处理的野生型小鼠在Arthus反应中皮肤产生的白细胞介素-6、肿瘤坏死因子-a和诱导型一氧化氮合酶的增加受到抑制，这与皮肤炎症的减少是平行的。这些结果表明硼替佐米治疗可能是治疗免疫复杂性疾病的一种有前途的策略。

To assess the role of ubiquitin-preteasome system in the immune-complex diseases, the cutaneous Arthus reaction was examined in wild type mice with or without proteasome inhibition by bortezomib. Edema and hemorrhage induced by immune complex challenge significantly decreased in bortezomib-treated wild type mice compared with untreated mice. Increased cutaneous production of interleukin-6, tumor necrosis factor-a and inducible nitric oxide synthase during Arthus reaction was inhibited in bortezomib-treated wild type mice relative to untreated mice, which paralleled the reduction in cutaneous inflammation. These results suggest that bortezomib treatment could be a promising strategy for treating immune-complex diseases.