Dopamine D1 receptor agonists may be useful therapeutic agents for the treatment of drug addiction and schizophrenia.

多巴胺D1受体的慢性激活诱导了对甲基苯丙胺行为敏感性的持续逆转。生化分析表明，慢性多巴胺D1受体激动作用调节甲基苯丙胺致敏大鼠纹状体中多巴胺D1受体信号的增强。该研究提供了实验证据，证明多巴胺D1受体激动剂可能是治疗药物成瘾和精神分裂症的有效药物治疗药物

Chronic activation of dopamine D1 receptors induces the persistent reversal ofbehavioral sensitization to methamphetamine. The biochemical analyses s u g g e s t t h a t chronic dopamine D1 receptor agonism adjusts the enhanced dopamine D1 receptorsignaling in the striatum of methamphetamine-sensitized rats. The study providesexperimental evidence that dopamine D1 receptor agonists may be useful aspharmacotherapeutic agents for the treatment of drug addiction and schizophrenia