Development and clinical applications of procedures for regulating the exosome formation based on the genetic traits of canine erythroid cells.

点击翻译按钮获取中文摘要

The HK phenotype in dog erythrocytes is suggested to be caused by disorders in lipid raft and exosome formations. However, the molecular basis of the disorders remains unknown. To clarify the mechanisms for regulating the exosome formation, we compared the protein contents of red cells, reticulocytes and exosomes from HK and normal dogs. Resultant candidate protein “Stomatin” was not a cause of HK phenotype. The genome-wide association study revealed that the causative gene located in canine chromosome 12 would be associated with the exosome and raft disorders.