Development of a novel transcutaneous vaccination device using a dissolving microneedle array.

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Transcutaneous immunization (TCI) is an attractive alternative vaccination route compared to the commonly used injection systems. We developed a dissolving microneedle array for use as a TCI device, and reported that TCI with the dissolving microneedle array induced an immune response against model antigens. In this study, I investigated the vaccination efficacy against influenza using this vaccination system. On influenza HA vaccination, robust antibody production was elicited in mice that provided complete protection against a subsequent influenza virus challenge. These findings demonstrate that TCI using a dissolving microneedle array can elicit large immune responses against infectious diseases. Based on these results, we are now preparing translational research for human clinical trials.