Biosynthesis of heparin proteoglycan (serglycin)

肝素是一种具有抗凝血活性的生物制品。它广泛应用于心肺手术、血液透析和动脉/静脉血栓的治疗。肝素加工过程中的生物合成过程，特别是高尔基体完成后碳水化合物链直到最终产物在分泌颗粒中储存的过程尚未阐明。目前的研究试图对这一过程进行详细的分析，得出“肝素酶”是这一过程的关键酶，新产生的肝素链非还原端可能具有特定的功能。

Heparin is a biological product having anticoagulant activity. It is widely used in heart-lung surgeries, hemodialysis, and in the treatment of arterial/venous thromboses. Biosynthetic processes involved in the processing of heparin, especially that of carbohydrate chains after completion in Golgi until the storage of the final products in secretion granules, have not been elucidated. The current research attempted to analyze this processes in detail, and has reached a conclusion that the “heparanase” is the key enzyme in this process and the newly generated non-reducing ends of heparin chains weresuggested to have specific functions.