Quality control of genomes of RNA viruses

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Little is known about quality control of genomes of RNA viruses such as in order to prevent accumulation of nonfunctional viral RNAs in cells. As a first approach to address possible molecular mechanism(s) involved in quality control degradation of viral RNA in virus lifecycles, we searched host cellular proteins that bind the untranslated regions (UTR) of hepatitis C virus RNA genome, and identified PSF, hnRNP-H and p54-nrb as 5’UTR IIId-binding factors. It may be likely that hnRNP-H is involved in the viral RNA stability via its interacting with the viral nucleocapsid protein.