Mesothelin and CA 125 expression in digestive carcinoma

消化道癌中间皮素和CA 125的表达

• 批准号: 23659289
• 负责人: SHIMAMURA Tsuyoshi
• 金额: $ 2.41万
• 依托单位: Hokkaido University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Challenging Exploratory Research
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011 至 2012
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23659289/
• 关键词: Mesothelin; C-ERC/mesothelin; リンパ管浸潤; 予後

In our analysis, 110 cases of gastric, 91 cases of colorectal and 61 cases of extrahepatic bile duct adenocarcinoma were immunohistochemically examined and the localization of mesothelin in luminal membrane was also evaluated to explore the clinicopathological significance of the mesothelin expression in these cancers. In addition, lymphatic invasion assay using the colon cancer cell line with enforced mesothelin expression was also performed to examine its biological role. “Luminal membrane positive” of mesothelin was significantly correlated with unfavorable patients’ outcome in these three types of adenocarcinoma. In addition, lymphatic invasion assay revealed that ERC/mesothelin significantly promoted the invasion of colorectal adenocarcinoma cell lines. In conclusion, mesothelin could be a novel therapeutic target to suppress the spread of tumors through the lymphatic system in various types of digestive cancers. (Br J Cancer. 2012, Int J Oncol.2012, J Gastroenterol. 2013)

本研究对110例胃癌、91例结直肠癌和61例肝外胆管腺癌组织进行了免疫组化检测，并对间皮素在癌组织管腔膜中的定位进行了评价，以探讨间皮素在胃癌、结直肠癌和肝外胆管癌中表达的临床病理意义。此外，还使用具有增强的间皮素表达的结肠癌细胞系进行淋巴侵袭测定以检查其生物学作用。在这三种类型的腺癌中，间皮素的"管腔膜阳性"与患者的不良预后显著相关。淋巴管侵袭实验显示ERC/mesothelin能显著促进大肠腺癌细胞系的淋巴管侵袭。总之，间皮素可能是一种新的治疗靶点，以抑制肿瘤通过淋巴系统在各种类型的消化道癌症的蔓延。(Br J Cancer. 2012，Int J Oncol.2012，J Gastroenterol. 2013年度）

项目成果

Taketomi Luminal membrane expression of mesothelin is significantly correlates with lymph node metastasis in colorectal cancer

Taketomi 间皮素管腔膜表达与结直肠癌淋巴结转移显着相关

• 发表时间: 2012
• 作者: F. Kawamata;S. Homma;T. Einama;H.Nishihara;H. Kamachi;Y. Kato;T. Kamiyama;S. Todo;A.
• 通讯作者: A.

Intracellular localization of mesothelin predicts patient prognosis of extrahepatic bile duct cancer

• DOI: 10.3892/ijo.2012.1662
• 发表时间: 2012-12-01
• 期刊: INTERNATIONAL JOURNAL OF ONCOLOGY
• 影响因子: 5.2
• 作者: Kawamata, Futoshi;Kamachi, Hirofumi;Todo, Satoru
• 通讯作者: Todo, Satoru

Membrane expression of mesothelin by immunostaining is a new potential biomarker for gastric cancer

免疫染色间皮素膜表达是胃癌新的潜在生物标志物

• 发表时间: 2012
• 作者: 山本絢子;齋藤紀先;櫛引美穂子;小笠原脩;木津綾乃;蔦谷昭司;秋元広之;小島佳也;萱場広之;川俣太 本間重紀 西原広史 永生高広 蒲 池浩文 高橋典彦 片岡昭彦神山俊哉 松野吉宏 藤堂省
• 通讯作者: 川俣太 本間重紀 西原広史 永生高広 蒲 池浩文 高橋典彦 片岡昭彦神山俊哉 松野吉宏 藤堂省

Taketomi Todo S at al. C-ERC/mesothelin provokes lymphatic invasion of colorectal adenocarcinoma

Taketomi Todo S 等人。

• 发表时间: 2013
• 期刊: J Gastroenterol. Epub
• 作者: Kawamata F;Kamiyama T Nishihara H
• 通讯作者: Kamiyama T Nishihara H

Intracellular localization of mesothelin prescribes the patients' prognosis of extrahepatic bile duct cancer

间皮素的细胞内定位决定肝外胆管癌患者的预后

• 发表时间: 2012
• 期刊: Int J Oncol
• 影响因子: 5.2
• 作者: Kawamata F;Kamachi H;Homma S;Kamiyama T;Taketomi A et al
• 通讯作者: Taketomi A et al