New classification of nociceptive sensory neurons and functional interaction between TRPV1 and TRPA1
New classification of nociceptive sensory neurons and functional interaction between TRPV1 and TRPA1
批准号:
23659323
负责人:
TOMINAGA Makoto
金额:
$2.41万
依托单位国家:
日本
项目类别:
Grant-in-Aid for Challenging Exploratory Research
财政年份:
2011
资助国家:
日本
项目状态:
已结题
起止时间:
2011 至 2012
中文摘要
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英文摘要
We found that capsiate, an ingredient contained in non-pungent capsicum, activates TRPA1. We found that Primary alcohols activate human TRPA1 channel in a carbon chain length-dependent manner. We found that two isothiocyanates from Wasabia japonica (6-MSITC, 6-MTITC) activate TRPA1. We found that 1,8-cineole, a TRPM8 agonist, is a novel natural antagonist of human TRPA1 upon intensive screening.
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ワサビから抽出される種々のイソチオシアネートによるTRPA1の活性化.
从芥末中提取的各种异硫氰酸酯激活 TRPA1。
DOI:
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发表时间:
期刊:
影响因子:
--
作者:
[内田邦敏, 三浦陽介, 永井雅, 富永真琴]
通讯作者:
富永真琴
自然科学研究機構岡崎統合バイオサイエンスセンター 細胞生理研究部門
国立自然科学研究所冈崎综合生命科学中心细胞生理学研究部
DOI:
--
发表时间:
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--
作者:
[]
通讯作者:
DOI:
10.1007/s00424-011-1069-4
发表时间:
2012-04-01
期刊:
PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY
影响因子:
4.5
作者:
[Komatsu, Tomoko, Uchida, Kunitoshi, Tominaga, Makoto]
通讯作者:
Tominaga, Makoto
Isothiocyanates from Wasabia japonica activate transient receptor potential ankyrin 1 channel.
来自山葵的异硫氰酸盐激活瞬时受体电位锚蛋白 1 通道。
DOI:
10.1093/chemse/bjs065
发表时间:
2012
期刊:
Chemical Senses
影响因子:
3.5
作者:
[Uchida K, Miura Y, Nagai M & Tominaga M.]
通讯作者:
Nagai M & Tominaga M.
1,8-cineole, a TRPM8 agonist, is a novel natural antagonist of human TRPA1.
1,8-cineole 是一种 TRPM8 激动剂,是人类 TRPA1 的新型天然拮抗剂。
DOI:
--
发表时间:
2012
期刊:
Molecular Pain
影响因子:
3.3
作者:
[Takaishi M, Fujita F, Uchida K, Yamamoto S, Sawada M, Hatai C, Shimizu M & Tominaga M]
通讯作者:
Shimizu M & Tominaga M
共 9 条
Analysis of regulation mechanisms of thermosensitive TRP channels and their involvement in immune responses
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批准号:23249012
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项目类别:Grant-in-Aid for Scientific Research (A)
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资助金额:$31.03万
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财政年份:2011
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负责人:TOMINAGA Makoto
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依托单位:
Physiological significance of thermosensitive TRPM2 channel
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批准号:19209006
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项目类别:Grant-in-Aid for Scientific Research (A)
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资助金额:$31.62万
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财政年份:2007
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负责人:TOMINAGA Makoto
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依托单位:
A 38-specific inhibitor, FR167653, reduces carotid intimal thickening and ameliorates insulin resistance in balloon-injured diabetic rats
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批准号:17590913
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$2.43万
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财政年份:2005
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负责人:TOMINAGA Makoto
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依托单位:
Mechanism of nociception : Structure-function relationship of capsaicin receptor and analysis of its regulation mechanism
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批准号:12670037
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$2.43万
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财政年份:2000
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负责人:TOMINAGA Makoto
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依托单位: