Development of image diagnosis and treatment for fluminant myocarditis

荧光性心肌炎的影像诊断与治疗进展

• 批准号: 23659416
• 负责人: MINAMINO Tetsuo
• 金额: $ 2.41万
• 依托单位: Osaka University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Challenging Exploratory Research
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011 至 无数据
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23659416/
• 关键词: 分子心臓病態学; 劇症型心筋症; ドラッグデリバリー; 劇症型心筋炎; 診断; 治療; リポソーム

The prognosis of fluminant myocarditis due to autoimmune myocarditis is poor. Thus, the development of new treatment for fluminant myocarditis is medical unmet need. We found that nano-size particles were accumulated in myocarditis hearts. Then, we have developed FK506(an immunosuppressant drug) coated with nano-size liposome. In rat myocarditis model, we found that liposomal FK506 prevented the cardiac dysfunction more than FK506 did. Liposomes are promising for developing new treatments for fluminant myocarditis.

自身免疫性心肌炎引起的暴发性心肌炎预后差。因此，开发治疗流行性心肌炎的新疗法是医学上尚未满足的需求。我们发现，纳米尺寸的颗粒积聚在心肌炎的心脏。在此基础上，研制了免疫抑制剂FK506纳米脂质体包被剂。在大鼠心肌炎模型中，我们发现FK506脂质体比FK506更能预防心功能不全。脂质体有望成为治疗流行性心肌炎的新药物。

项目成果

Amelioration of cerebral ischemia-reperfusion injury based on liposomal drug delivery system with asialo-erythropoietin

• DOI: 10.1016/j.jconrel.2012.02.004
• 发表时间: 2012-05-30
• 期刊: JOURNAL OF CONTROLLED RELEASE
• 影响因子: 10.8
• 作者: Ishii, Takayuki;Asai, Tomohiro;Oku, Naoto
• 通讯作者: Oku, Naoto

炎症性疾患治療用医薬組成物

用于治疗炎症性疾病的药物组合物

• 发表时间: 2012

Development of anti-HB-EGF immunoliposomes for the treatment of breast cancer

• DOI: 10.1016/j.jconrel.2011.10.010
• 发表时间: 2012-06-10
• 期刊: JOURNAL OF CONTROLLED RELEASE
• 影响因子: 10.8
• 作者: Nishikawa, Kaoru;Asai, Tomohiro;Minamino, Tetsuo
• 通讯作者: Minamino, Tetsuo