Development of image diagnosis and treatment for fluminant myocarditis

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The prognosis of fluminant myocarditis due to autoimmune myocarditis is poor. Thus, the development of new treatment for fluminant myocarditis is medical unmet need. We found that nano-size particles were accumulated in myocarditis hearts. Then, we have developed FK506(an immunosuppressant drug) coated with nano-size liposome. In rat myocarditis model, we found that liposomal FK506 prevented the cardiac dysfunction more than FK506 did. Liposomes are promising for developing new treatments for fluminant myocarditis.