The analysis of epigenetic changes in GH-IGF-1 axis of small for gestational age rats

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The hormonal factors involved in catch-up growth in the small for gestational age (SGA) are unknown. To reveal the mechanism underlying growth failure in SGA, we analyzed growth hormone (GH)/ insulin-like growth factor (IGF)-1 axis in a rat model. In SGA and non-catch up growth (SGA-NCG) rats, hepatic growth hormone receptor (GHR) expression was reduced. We revealed that the reduction of GHR expression is caused by elevation of miR-322 expression in the liver of SGA-NCG rats. We further found that DNA methylation in the miR-322 coding region is reduced in the liver of SGA-NCG rats and thatthese changes in the expression of GHR and miR-322 are trans-generational.