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The genetic immunotherapy by novel nasal spray vaccine for melanomausing the next generation type virus vector

The genetic immunotherapy by novel nasal spray vaccine for melanomausing the next generation type virus vector
使用下一代病毒载体的新型鼻喷雾疫苗治疗黑色素瘤的基因免疫疗法
批准号:
23659549
负责人:
KAWANO Mitsuo
金额:
$2.33万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Challenging Exploratory Research
财政年份:
2011
资助国家:
日本
项目状态:
已结题
起止时间:
2011 至 2012

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中文摘要
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英文摘要
To establish a novel genetic immunotherapy instead of conventional chemotherapy and radiotherapy against refractory malignant melanoma, we have developed the parainfluenza type 2 virus vector introduced TRP-2 gene known as melanoma differentiation antigen or Ag85B gene inducing strong Th1 adjuvant activity. We analyzed the antitumor effect and the immune mechanisms by intranasal administrationto melanoma like model mice using the next generation spray vaccine for melanoma.
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DOI: --
发表时间: 2013
期刊:
影响因子: --
作者: [山本秀孝, 内田美香, 坂倉百合香, 出口小百合, 紀平佐保子, 植松淳, 河野光雄, 鶴留雅人, 駒田洋]
通讯作者: 駒田洋
DOI: --
发表时间:
期刊:
影响因子: --
作者: [紀平佐保子, 植松淳, 山本秀孝, 河野光雄, 鶴留雅人, 駒田洋]
通讯作者: 駒田洋
Identification of amino acids of simian virus 41 (SV41) fusion protein that convert parainfluenza virus 5 fusion protein to a protein which specifically interacts with SV41 hemagglutininneuraminidase by substitution.
鉴定猿猴病毒 41 (SV41) 融合蛋白的氨基酸,将副流感病毒 5 融合蛋白转化为通过取代与 SV41 血凝素神经氨酸酶特异性相互作用的蛋白。
DOI: --
发表时间: 2011
期刊:
影响因子: --
作者: [Masato Tsurudome, Mito Nakahashi, Yoshiaki Matsushima, Machiko Nishio, Mitsuo Kawano, Hiroshi Komada, Tetsuya Nosaka]
通讯作者: Tetsuya Nosaka
DOI: --
发表时间: 2013
期刊:
影响因子: --
作者: [紀平佐保子, 植松淳, 山本秀孝, 河野光雄, 鶴留雅人, 駒田洋]
通讯作者: 駒田洋
11
    Suppression of breast cancer metastasis using the next generation nasal spray vaccine
    • 批准号:
      25670441
    • 项目类别:
      Grant-in-Aid for Challenging Exploratory Research
    • 资助金额:
      $2.41万
    • 财政年份:
      2013
    • 负责人:
      KAWANO Mitsuo
    • 依托单位:
    The mucosal immunotherapy using virus vectors possessing specific expression capacity of a large cytokine in mucosal membranes
    • 批准号:
      19591163
    • 项目类别:
      Grant-in-Aid for Scientific Research (C)
    • 资助金额:
      $2.91万
    • 财政年份:
      2007
    • 负责人:
      KAWANO Mitsuo
    • 依托单位: