Comprehensive genetic analysis ofParkin gene in psychiatric diseases

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Homozygous or compound heterozygous Parkinmutations cause autosomal recessive juvenile parkinsonism (ARJP). ARJP patientsand heterozygous Parkinmutant carrier often present with psychiatric diseases as “common diseases” including mood disorder or schizophrenia. We experianced an ARJP patient with dopamine dysregulation syndrome who heterozygously harbored a parkinmutation. In comprehensive genetic analysis of Parkin, we found copy number variations in 3 schizophrenic patients out of fifty.