Development of molecular target radiation therapy from molecular target imaging

本研究是开发一种新概念的试验，使分子靶向药物能够用于癌症的放射治疗。这一概念不仅可以实现分子靶成像，也可以实现分子靶放射治疗。在这项研究中，我们使用了我们新的分子成像化合物PYK来检测EGFR-TK。该化合物在EGFR-TK的体内成像方面具有很大的潜力。总之，分子靶向放射治疗是可以实现的，尽管需要额外的化合物来提高靶标摄取或靶非靶比。

This study is a trial to develop a novel concept which makes molecular target drug for cancer enable radiation therapy . This concept can allow not only molecular target imaging and also molecular target radiation therapy. In this study, we use our new molecular imaging compound, PYK for EGFR-TK. This compound has a great potential for in vivo imaging for EGFR-TK. In conclusion, molecular target radiation therapy might be achieved although additional compounds are required to improve target uptake or target to non-target ratio.