Development of molecular probe for imaging of malaria infection

我们开始开发用于疟疾感染成像的分子探针，这是世界上最重要的感染，并推进了基于抗疟疾药物基本骨架或与淀粉样蛋白有亲和力的化合物的候选分子探针的合成。成功地合成了抗疟药物放射性碘标记喹啉、喹啉的基本骨架吖啶衍生物及其放射性碘标记化合物、与淀粉样蛋白具有亲和力的苯乙烯色酮衍生物及其放射性碘标记衍生物。然而，对体外疟原虫的直接标记尚未完成。

We started to develop the molecular probe for imaging of malaria infection which is the most important worldwide infection and advanced the synthesis of the candidates molecular probe based on the fundamental skeleton of antimalarial drugs or the compound which shows an affinity to amyloid. It succeeded in synthesis of the radioactive-iodine labeled quinacrine as antimalarial-drugs, the acridine derivatives which is a fundamental skeleton of quinacrine and its radioactive-iodine labeled compound, and the styrylchromone derivatives which shows an affinity for amyloid and its radioactive-iodine labeled derivatives.However,the direct labeling of the malaria parasite outside a body is not completed.