In vivo tracking of transplanted cells using manganese-enhanced magnetic resonance imaging(MEMRI) and assessment of cardiac function for mouse myocardial infarction

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In-vivo tracking of transplanted Mn^<2+>-labeled cells with Magnetic Resonance Imaging(MRI) was attempted to visualize the localization of migrated cells at high spatial resolution in mouse myocardial infarction and the long term regenerative therapeutic effects. MRI measured ejection fraction(EF) was lower than EF measured by ultrasound. However, EF of MRI showed a good correlation to that of ultrasound. Repeat measurement showed slight change of EF in both MRI and ultrasound. Transplanted Mn^<2+>-labeled cells were visualized by MRI up to 4 weeks after transplantation. Cell tracking with manganese-enhanced MRI and assessment of cardiac function promise to be a standard technique for the cell selection and delivery.