Preliminary experiment for the application of MR elastography for non invasive measurement of intracranial environment

本研究的目的是利用磁共振弹性成像技术（MRI）的新兴应用，开发一种新的微创方法来监测颅内压、颅内顺应性和大脑自动调节。采用已知力学特征的创伤性脑损伤动物模型进行MRE成像的基础实验。此外，建立了动物模型（猪）和人体的力学性能（断裂强度和杨氏模量）数据库，便于在未来的MRE应用中对数据进行验证。

The purpose of present study is to develop novel minimally invasive method to monitor intracranial pressure, intracranial compliance, and cerebral autoregulation by applying magnetic resonance elastotraphy MRE)technique, which is emerging application of magnetic resonance imaging (MRI).The basic experiments for imaging by MRE were conducted using animal traumatic brain injury (TBI) model with known mechanical characteristics. In addition, database for mechanical property (breaking strength and Young's modulus) was developed in both animal model (swine) and human, which would facilitate to validate the data in the future application of MRE.