Evaluation of mechanism of ossification of the posterior longitudinal ligament and identification of candidate disease gene associated with ossification of the posterior longitudinal ligament

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Human induced pluripotent stem cells were established from the patients with OPLL. We performed osteogenic induction and ligamentocyte induction from the OPLL-iPS. No difference was observed in osteblastic induction potential between the OPLL-iPS and iPS from healthy control patients. Gene expression profiling in ligamentocyte-precursor cells induced from OPLL-iPS was evaluated. Comparing gene expression profile with that of the iPS from healthy control patients, candidate genes which may be associated with mechanism of ectopic ossification of the posterior longitudinal ligament in OPLL patients were selected.