Precision surface machining to bearing surface of artificial joint
Precision surface machining to bearing surface of artificial joint
批准号:
23659728
负责人:
NAKANISHI Yoshitaka
金额:
$2.66万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Challenging Exploratory Research
财政年份:
2011
资助国家:
日本
项目状态:
已结题
起止时间:
2011 至 2013
中文摘要
超高分子量聚乙烯(UHMWPE)被广泛用作聚合物-硬关节假体中的关节面材料;然而,磨损颗粒被认为是植入物长期骨质溶解和松动的主要因素。虽然常规接头用Co-Cr-Mo合金的常用表面粗糙度为10-20纳米,但经过精密加工后的合金新表面粗糙度为1-2纳米的分散凹面。精密表面加工方法是一种典型的研磨方法,但研磨液与被加工表面的关系一直受到严格控制。新的表面减少了UHMWPE的磨损量,这将确保关节的长期耐用性。新的表面增大了UHMWPE颗粒的尺寸。将细胞与颗粒一起培养。在新表面上产生的磨损颗粒抑制IL-6的产生。
英文摘要
Ultra-high molecular weight polyethylene (UHMWPE) is widely used as bearing material in a polymer-on-hard joint prosthesis; however, the wear particles are considered to be a major factor in long-term osteolysis and loosening of implants. Although the generally used surface on Co-Cr-Mo alloy for a conventional joint has 10-20 nanometer roughness, the new surface on the alloy with finishing through the precision machining has 1-2 nanometer roughness scattered concavo-shapes. The precision surface machining method is a kind of the typical lapping method, but relationship between slurry and machining surface had been strictly controlled. The new surface reduced the amount of UHMWPE wear, which would ensure the long-term durability of joints. The new surface enlarged the size of UHMWPE particles. Cells were cultured with the particles. The wear particles generated on the new surface inhibited the production of IL-6.
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DOI:
--
发表时间:
2013
期刊:
臨床バイオメカニクス
影响因子:
--
作者:
[大久保立樹・室町泰徳, 中西義孝,日垣秀彦,三浦裕正,水田博志,岩本幸英]
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DOI:
--
发表时间:
2012
期刊:
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--
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--
发表时间:
2011
期刊:
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[Tanaka, T, 中西義孝]
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[M.Nishi, R.Matsumoto, J.Dong, T. Uemura, Takaaki Tanaka, 片桐岳信, 伊熊駿]
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伊熊駿
共 45 条
Food imprinting in goats and its potential application to weed control on grazed sward
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批准号:21580333
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$3.08万
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财政年份:2009
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负责人:NAKANISHI Yoshitaka
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依托单位:
海外基金