Precision surface machining to bearing surface of artificial joint
Precision surface machining to bearing surface of artificial joint
批准号:
23659728
负责人:
NAKANISHI Yoshitaka
金额:
$2.66万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Challenging Exploratory Research
财政年份:
2011
资助国家:
日本
项目状态:
已结题
起止时间:
2011 至 2013
中文摘要
超高分子量聚乙烯(UHMWPE)作为承载材料广泛应用于硬聚合物关节假体中;然而,磨损颗粒被认为是长期骨溶解和植入物松动的主要因素。常规接头上常用的Co-Cr-Mo合金表面粗糙度为10 ~ 20纳米,而精加工后的合金表面粗糙度为1 ~ 2纳米,呈分散凹凸状。精密表面加工方法是一种典型的研磨加工方法,但浆料与加工表面之间的关系受到严格控制。新的表面减少了超高分子量聚乙烯的磨损量,这将确保接头的长期耐用性。新表面增大了超高分子量聚乙烯颗粒的尺寸。用颗粒培养细胞。新表面产生的磨损颗粒抑制了IL-6的产生。
英文摘要
Ultra-high molecular weight polyethylene (UHMWPE) is widely used as bearing material in a polymer-on-hard joint prosthesis; however, the wear particles are considered to be a major factor in long-term osteolysis and loosening of implants. Although the generally used surface on Co-Cr-Mo alloy for a conventional joint has 10-20 nanometer roughness, the new surface on the alloy with finishing through the precision machining has 1-2 nanometer roughness scattered concavo-shapes. The precision surface machining method is a kind of the typical lapping method, but relationship between slurry and machining surface had been strictly controlled. The new surface reduced the amount of UHMWPE wear, which would ensure the long-term durability of joints. The new surface enlarged the size of UHMWPE particles. Cells were cultured with the particles. The wear particles generated on the new surface inhibited the production of IL-6.
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Nano-Level Surface Texturing on Co-Cr-Mo alloy Inhibits Macrophage Activation in Joint Prostheses
Co-Cr-Mo 合金的纳米级表面纹理抑制关节假体中巨噬细胞的激活
DOI:
--
发表时间:
2012
期刊:
影响因子:
--
作者:
[Hirakawa A, Shimizu K, Fukumitsu H, Soumiya H, Iinuma M, Furukawa S, Yoshioka Kiyoko, Yoshitaka NAKANISHI]
通讯作者:
Yoshitaka NAKANISHI
人工関節の表面研磨法が摩耗粉とサイトカイン産生に与える影響
人工关节表面抛光方法对磨损碎片和细胞因子产生的影响
DOI:
--
发表时间:
2013
期刊:
臨床バイオメカニクス
影响因子:
--
作者:
[大久保立樹・室町泰徳, 中西義孝,日垣秀彦,三浦裕正,水田博志,岩本幸英]
通讯作者:
中西義孝,日垣秀彦,三浦裕正,水田博志,岩本幸英
生体反応を制御できる加工技術~整形インプラントへの応用~
可控制生物反应的加工技术~在骨科植入物中的应用~
DOI:
--
发表时间:
2011
期刊:
影响因子:
--
作者:
[Hiroki Sugita, Minhye Kim, Ji Mao, Yoshikazu Yasuda, Mayu Habiro, Shohei Shinozaki, Shingo Yasuhara, Nobuyuki Shimizu,J.A.Jeevendra Martyn, Masao Kaneki, 荒磯ひろみら, 古株彰一郎, 右田啓介, 中西義孝]
通讯作者:
中西義孝
人工関節摺動面で生じるUHMWPE摩耗粉の調査と細胞に与える影響
人工关节滑动表面产生的UHMWPE磨损颗粒及其对细胞影响的研究
DOI:
--
发表时间:
2014
期刊:
影响因子:
--
作者:
[Nukazawa K., Kazama S., Watanabe K., 近浦裕斗,西真生,中島雄太,三浦裕正,日垣秀彦,水田博志,岩本幸英,中西義孝]
通讯作者:
近浦裕斗,西真生,中島雄太,三浦裕正,日垣秀彦,水田博志,岩本幸英,中西義孝
バイオトライボロジー研究の現状
生物摩擦学研究现状
DOI:
--
发表时间:
2012
期刊:
機械の研究
影响因子:
--
作者:
[Kokabu S, Gamer L, Cox K, Tsuji K, Raz R, Economides A, Katagiri T, and Rosen V, Matsubara T., 中西義孝]
通讯作者:
中西義孝
共 45 条
Food imprinting in goats and its potential application to weed control on grazed sward
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批准号:21580333
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$3.08万
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财政年份:2009
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负责人:NAKANISHI Yoshitaka
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依托单位:
海外基金