Tumor-targeted chemotherapy with the nanopolymer-based drug NC-6004 for oral squamous cell carcinoma

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Cisplatin (CDDP) has been a key drug for chemotherapy in patients with head and neck squamous cell carcinoma (HNSCC). Nephrotoxicity is one of its adverse reactions. To increase its antitumor effects and reduce such toxicity problems, polymeric micelles carrying CDDP (NC-6004) have been developed. This study was designed to evaluate the efficacy and safety of NC-6004. To investigate the antitumor and nephrotoxic effects of NC-6004, nude mice bearing OSC-19 were administered drugs. Both drugs showed equivalent antitumor effects. Mice with CDDP developed renal cell apoptosis; however, those injected with NC-6004 were almost free of renal cell injury. Moreover, in an orthotopic tongue cancer model, NC-6004 reduced the rate of lymph node metastasis to lower than that with CDDP. In conclusion, considering the potential advantages, NC-6004 represents a significant structural improvement in the development of a platinum complex.