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Development of glaucoma stent surgery and histological analysis of anterior chamber angle

青光眼支架手术进展及前房角组织学分析

基本信息

批准号：
23659809
负责人：
UEDA Jun
金额：
$ 2.33万
依托单位：
Niigata University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Challenging Exploratory Research
财政年份：
2011
资助国家：
日本
起止时间：
2011 至 2012
项目状态：
已结题

项目摘要

The aim of this study is to develop a new glaucoma surgery obtaining better efficiency lowering intraocular pressure by means of opening Schlemm’s canal persistently, refining conventional trabeculotomy. We used extirpated pig eyes for the experiments. Long trabeculotome (150゜) was inserted into the Schlemm’s canal and trabeculotomy ab interno was performed using newly developed double-blade goniotomy knife, and trabecular tissue of 200μm width was removed. Double-blade crescent knife, the first trial model, cannot surely make parallel incision, and the trabeculotome extruded from the single incision line. However, double-blade slit knife, the second one, smoothly made double incision line and enabled extirpation of trabecular tissue of 200μm width. Electron microscopic pictures of the knife after the experiment, revealed nicked tip of the blade. We are now examining alternative materials of trabeculotome to improve this surgical procedure safe and sure.

本研究的目的是开发一种新的青光眼手术，通过持续开放Schlemm管，改进传统的小梁切开术，以获得更好的效果和降低眼压。我们用摘除的猪眼做实验。将长骨小梁(15 0゜)植入Schlemm管内，用新研制的双刃刀行内侧小梁切开术，切除宽度为2 0 0μm的小梁组织。双刃新月刀作为第一个试验模型，不一定能进行平行切开，小梁从单切口线上突出。而第二把双刃裂隙刀顺利完成双切口线，可摘除宽度为200μm的小梁组织。实验后的电子显微镜照片显示，刀片尖端有划痕。我们现在正在研究替代的小梁刀材料，以安全可靠地改进这一手术过程。