Development of new therapeutic method of aspiration pneumonitis on saliva protein promoting by PDE

PDE促进唾液蛋白治疗吸入性肺炎新方法的开发

• 批准号: 23659943
• 负责人: MURATA TAKU
• 金额: $ 2.33万
• 依托单位: Mie University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Challenging Exploratory Research
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011 至 2012
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23659943/
• 关键词: 唾液腺; 誤嚥性肺炎

Causes of aspiration pneumonitis are oral bacteria et al. Saliva proteins reduce oral bacteria et al, and those expression and secretion are regulated by cAMP, and cAMP are controlled by phosphodiesterase (PDE).In rat submandibular gland main PDEs are PDE3 and PDE4. In isolated rat submandibular acini cells PDE3 was expressed, but not in duct cells. Myoepithelial cells were found in both cells. There were no change in submandibular gland of PDE3 knock out mouse. PDE4A and PDE7B were wxpressed in submandibular gland. It is suggested that each PDE regulated the expression and secretion of saliva protein.

吸入性肺炎的病因有口腔细菌等。唾液蛋白抑制口腔细菌等，其表达和分泌受cAMP调控，cAMP受磷酸二酯酶(PDE)控制。在大鼠颌下腺中，PDE3和PDE4是主要的PDEs。在分离的大鼠颌下腺泡细胞中，PDE3有表达，但在导管细胞中不表达。两种细胞均可见肌上皮细胞。PDE3基因敲除小鼠颌下腺无明显变化。PDE4A和PDE7B在颌下腺有表达。提示各PDE对唾液蛋白的表达和分泌均有调节作用。

项目成果

Expression of phosphodiesterase3 in isolated rat submandibular cells

磷酸二酯酶3在大鼠离体颌下细胞中的表达

• 发表时间: 2012
• 作者: 関田 素子、清水 香澄、村田 琢、田川俊郎;他
• 通讯作者: 他