Hematopoietic cells regulate bone metabolism

骨髓脂肪组织随年龄增长而增加。因此，我们探讨了骨髓中脂肪组织对骨形成和骨吸收的影响。促进破骨细胞形成的Wnt5a在关节炎模型小鼠中表达增加。Wnt5a抑制剂Sfrp5的表达降低。用strp5处理可以抑制Wnt5a对破骨细胞形成的刺激作用。脂肪组织高表达strp5。在关节炎小鼠中强制表达strp5可消除与关节炎相关的骨破坏。

Adipose tissues in bone marrow are increased with aging. We therefore explored effects of adipose tissues in bone marrow on bone formation and resorption. The expressionof Wnt5a, which promotes osteoclast formation, was increased in arthritis model mice.The expression of Sfrp5, an inhibitor of Wnt5a, was decreased. Treatment with Sfrp5 inhibited the stimulatory effect of Wnt5a on osteoclast formation. Adipose tissues highly expressed Sfrp5. Enforced expression of Sfrp5 in arthritis mice abrogated bone destruction associated with arthritis.