Defective autophagy in aged periodontal tissue

在这项研究中，我们研究了自噬在牙周组织中的作用。牙周膜细胞在平衡牙周组织的动态平衡、伤口愈合和组织再生方面起着至关重要的作用。我们发现，自噬积极地调节细胞外基质蛋白的合成和PDL细胞对各种环境应激的应激反应。我们还发现，在营养缺乏、炎性细胞因子和氧化应激等衰老诱导刺激下，衰老的PDL细胞自噬功能存在缺陷。

In this study, we examined the roles of autophagy in periodontal tissue. Periodontal ligament (PDL) cells are crucial for balancing the homeostasis, wound healing and tissue regeneration in periodontal tissue. We found that autophagy actively regulated the synthesis of ECM protein and stress response in PDL cells against various environmental stress. We also found that autophagy was defective in aged PDL cells those were exposed to senescence inducing stimulus, such as nutrient starvation, inflammatory cytokines and oxidative stress.