Defective autophagy in aged periodontal tissue

在这项研究中，我们研究了自噬在牙周组织中的作用。牙周膜细胞对牙周组织的平衡、伤口愈合和组织再生至关重要。我们发现，自噬在PDL细胞对各种环境应激的反应中积极调节ECM蛋白的合成。我们还发现，自噬是缺陷的老化PDL细胞暴露于衰老诱导的刺激，如营养饥饿，炎症细胞因子和氧化应激。

In this study, we examined the roles of autophagy in periodontal tissue. Periodontal ligament (PDL) cells are crucial for balancing the homeostasis, wound healing and tissue regeneration in periodontal tissue. We found that autophagy actively regulated the synthesis of ECM protein and stress response in PDL cells against various environmental stress. We also found that autophagy was defective in aged PDL cells those were exposed to senescence inducing stimulus, such as nutrient starvation, inflammatory cytokines and oxidative stress.