Effects of A2A-receptor antagonists on PD models via autophagy regulation.

考虑到咖啡因对帕金森病的预防作用，我们使用细胞模型研究了咖啡因类似物通过自噬调节对PD细胞模型的影响，用咖啡因类似物处理的HeLa细胞显示出通过mTOR非依赖性途径，特别是通过cAMP抑制自噬的特征。此外，其中一种在一些细胞系中诱导细胞死亡，但在其他细胞系中不诱导细胞死亡。总之，一些咖啡因类似物可能是抗癌药物的潜在候选者。

Considering caffeine preventive effects on Parkinson's disease, we examined effects of caffeine analogues on PD cellular models via autophagic regulation using cellular models.HeLa cells treated with a caffeine analogue have shown characteristics of autophagic inhibition via mTOR independent pathway, especially via cAMP. Also, one of them induced cell death in some cell lines but not in others. Taken together, some caffeine analogues might be potential candidates for anti-cancer agents.