Evolution of neo-mineral knowledge understanding CKD-MBD

高磷血症是慢性肾病患者和血液透析患者血管钙化的原因之一，并与心源性死亡率相关。近年来，一些研究报道了唾液磷酸盐浓度与肾功能、血清磷酸盐浓度之间的关系，以及高磷血症治疗的潜在靶点。然而，目前还不清楚无机磷酸盐（Pi）的处理机制在唾液腺。在本研究中，我们研究了唾液腺中的Pi处理。在喂食高Pi饮食的野生型小鼠中，血浆和唾液Pi的水平显著高于喂食低Pi饮食的小鼠。在Npt 2b +/-小鼠中，唾液Pi浓度与Npt 2b +/+小鼠相比显著增加。提示唾液磷水平与日粮磷含量有关，唾液腺在体内磷平衡系统中起重要作用。

Hyperphosphatemia is contributes to vascular calcification in patients with chronic kidney disease and hemodialysis patients and is associated with cardiac mortality. Recently, several studies reported the relationship among salivary phosphate concentration, renal function, serum phosphate concentration, and the potential target of new therapy for hypephosphatemia. However, it is unclear the inorganic phosphate (Pi) handling mechanisms in salivary glands. In the present study, we investigated the Pi handling in salivary glands. In wild-type mice fed a high Pi diet, the levels of plasma and salivary Pi are significantly higher than those in mice fed a low Pi diet. In Npt2b+/- mice, the salivary Pi concentrations were significantly increased compared with those in Npt2b+/+ mice. The present study suggests that salivary Pi levels correlate with dietary Pi content, and salivary glands paly a role for phosphate homeostasis system in the body.