Axonal regeneration via regulation of point contacts

通过点接触调节轴突再生

• 批准号: 23700376
• 负责人: KUBOYAMA TOMOHARU
• 金额: $ 2.75万
• 依托单位: University of Toyama
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011 至 2013
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23700376/
• 关键词: 細胞接着; 脊髄損傷; 軸索再生; プロテオグリカン; プロテインキナーゼA; パキシリン; p21-activated kinase; コンドロイチン硫酸プロテオグリカン; dystrophic endball; 細胞接着班

I previously clarified that enhancing of point contact dynamics promoted axonal regeneration in cultured system that mimicked failure of axonal regeneration in the injured central nervous system. In this study, I showed that protein kinase A, p21-activated kinase and paxillin were involved in the above regeneration mechanisms. This study proposes novel targets for axonal regeneration in spinal cord injury, etc.

我先前阐明，点接触动力学的增强促进了培养系统中的轴突再生，模拟了受损中枢神经系统中轴突再生的失败。在本研究中，我发现蛋白激酶A，p21激活的激酶和桩蛋白参与了上述再生机制。本研究为脊髓损伤等的轴突再生提供了新的靶点。

项目成果

Screening on functions from some Chinese herbs for spinal cord injury.

部分中药治疗脊髓损伤的作用筛选.

• 发表时间: 2012
• 期刊: Chinese Journal of Experimental Traditional Medical Formulae
• 作者: Wang XH;Zhu H;Konno K;Tohda C;Kazuma K;Kuboyama T;Miyanaga S
• 通讯作者: Miyanaga S

Improvement of motor dysfunction in acute and chronic phases in spinal cord injury mice by a crude drug-derived compound.

通过生药衍生化合物改善脊髓损伤小鼠急性期和慢性期的运动功能障碍。

• 发表时间: 2014
• 作者: Tanabe N.;Kuboyama T.;Kazuma K.;Konno K.;Tohda C.
• 通讯作者: Tohda C.

DR improves memory impairment in Alzheimer's disease model mice, 5XFAD, and attenuates amyloid β-induced axonal atrophy

DR 改善阿尔茨海默病模型小鼠 5XFAD 的记忆障碍，并减轻β淀粉样蛋白诱导的轴突萎缩

• 发表时间: 2014
• 作者: Yang Z.;Kuboyama T.;Tohda C.
• 通讯作者: Tohda C.

Signal transduction underlying chondroitin sulfate proteoglycan-mediated inhibition of axon regeneration

硫酸软骨素蛋白聚糖介导的轴突再生抑制作用的信号转导

• 发表时间: 2011
• 作者: Kuboyama T;Silver J;Tohda C;Kamiguchi H
• 通讯作者: Kamiguchi H

The recovery of motor function by a crude drug and its active constituent in spinal cord injured mice.

生药及其活性成分对脊髓损伤小鼠运动功能的恢复。

• 发表时间: 2014
• 作者: Tanabe N.;Kuboyama T.;Kazuma K.;Konno K.;Tohda C.
• 通讯作者: Tohda C.