Elucidation of the Mechanisms that Netrin-1 Guides Commissural Axons to the Ventral Midline
Elucidation of the Mechanisms that Netrin-1 Guides Commissural Axons to the Ventral Midline
批准号:
23700379
负责人:
YAMAUCHI Kenta
金额:
$2.83万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Young Scientists (B)
财政年份:
2011
资助国家:
日本
项目状态:
已结题
起止时间:
2011 至 2012
中文摘要
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英文摘要
Chemotropism is a fundamental theory of axon guidance. However, this theory has not been rigorously tested. In this study , I studied whether netrin-1 guides commissural axons ventrally in a chemotrophic manner. Expression patterns of netrin-1 mRNA and protein during ventral migration of commissural axons were examined. Additionally , which netrin-1 expression is necessary and sufficient for ventrally directed extension of commissural axons was tested.
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Temporally- and spatially regulated generation of distinct descendants by sonic hedgehog-expressing progenitors in the forebrain
前脑中表达声音刺猬的祖细胞在时间和空间上调节不同后代的产生
DOI:
10.1002/dneu.20861
发表时间:
2012
期刊:
Dev Neurobiol
影响因子:
3
作者:
[Wada Y, Yamauchi K, Murakami F, Tanabe Y]
通讯作者:
Tanabe Y
Cortical excitatory neuron are divided into two distinct groups by their initial projection patterns
皮质兴奋性神经元根据其初始投射模式分为两个不同的组
DOI:
--
发表时间:
期刊:
影响因子:
--
作者:
[T.Namita, 他3名, Hatanaka Y]
通讯作者:
Hatanaka Y
Netrin-1 Is a Determinant of Commissural Axon Growth within the CNS.
Netrin-1 是中枢神经系统内连合轴突生长的决定因素。
DOI:
--
发表时间:
2012
期刊:
影响因子:
--
作者:
[Yamauchi K, Yamazaki M, Sakimura K, Umebayashi M, Murakami F.]
通讯作者:
Murakami F.
Role of neuropilin-2 signaling in the ipsilateral growth of midbrain dopaminergic axons.
Neuropilin-2 信号传导在中脑多巴胺能轴突同侧生长中的作用。
DOI:
--
发表时间:
2012
期刊:
影响因子:
--
作者:
[Torigoe M, Yamauchi K, Tamada A, Matsuda I, Aiba A, Castellani V, Murakami F.]
通讯作者:
Murakami F.
Role of neuropilin-2 signaling in the ipsilateral growth of midbrain dopaminergic axons
Neuropilin-2信号在中脑多巴胺能轴突同侧生长中的作用
DOI:
--
发表时间:
2012
期刊:
影响因子:
--
作者:
[Torigoe M, Yamauchi K, Tamada A, Matsuda I, Aiba A, Castellani V, Murakami F.]
通讯作者:
Murakami F.
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