Adenosine A1 receptor interacts with mGluR1 and regulates motor learning

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In various cell types, G protein-coupled receptors (GPCRs) form heteromeric complexes and cooperatively mediate the intrigue cellular responses.Although heteromeric GPCR complexes are suggested to occur in many neurons, their contribution to neuronal function remains unclear. We address this question using two GPCRs expressed in cerebellar Purkinje cells: adenosine A1 receptor, which regulates neurotransmitter release and neuronal excitability in central neurons and type -1 metabotropic glutamate receptor, which mediates cerebellar long-term depression, a form of synaptic plasticity crucial for cerebellar motor learning.