Imaging study of the physiological relationship between dopaminergic neurons and memory central

多巴胺能神经元与记忆中枢生理关系的影像学研究

• 批准号: 23700405
• 负责人: UENO Kohei
• 金额: $ 2.75万
• 依托单位: 公益財団法人東京都医学総合研究所 (2012)Tokyo Metropolitan Organization for Medical Research (2011)
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011 至 2012
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23700405/
• 关键词: 分子; 細胞神経科学; イメージング; ショウジョウバエ; ドパミン; 神経可塑性

The plastic change in the synaptic transmission is underlying learning and memory formation. Recent studies have suggested that dopamine is important for the plasticity, while the physiological mechanisms is unclear. In Drosophila, dopamine signaling is also required for olfactory aversive memory that is induced by odor and electrical shock. Previously, I have reported that simultaneous stimulation of odor and shock inputs induced plastic change in the mushroom body, olfactory memory center, in isolated brain via dopamine signaling. Here, I examined the relationship between dopamine signaling and neural plasticity in mushroom body, and found that dopamine release is occurred when mushroom body is activated by simultaneous inputs from odor and shock.

突触传递的可塑性变化是学习和记忆形成的基础。最近的研究表明，多巴胺在可塑性中起重要作用，但其生理机制尚不清楚。在果蝇中，气味和电击诱导的嗅觉厌恶记忆也需要多巴胺信号。此前，我曾报道过，气味和电击输入的同时刺激通过多巴胺信号在孤立的大脑中诱导蘑菇体--嗅觉记忆中心--的可塑性变化。在这里，我研究了蘑菇体中多巴胺信号与神经可塑性的关系，发现当气味和电击的同时输入激活蘑菇体时，就会发生多巴胺释放。

项目成果

Perlecan regulates bidirectional Wnt signaling at the Drosophila neuromuscular junction.

• DOI: 10.1083/jcb.201207036
• 发表时间: 2013-01-21
• 期刊: The Journal of cell biology
• 作者: Kamimura K;Ueno K;Nakagawa J;Hamada R;Saitoe M;Maeda N
• 通讯作者: Maeda N

in vitro imaging analysis of neural plasticity in mushroom body neurons

蘑菇体神经元神经可塑性的体外成像分析

• 发表时间: 2011
• 作者: Yu Hayashi;Kazuya Sakai;Kosuke Yasuda;Julia Nguyen;Reiko Ando;Shigeyoshi Itohara;上野耕平;Genetic analysis of the REM sleep center and its developmental origin;上野耕平
• 通讯作者: 上野耕平

Correlated Activation of Dopamine Receptors Is An Essential for Associative Synaptic Plasticity Relevant To Olfactory Aversive Memory

多巴胺受体的相关激活对于与嗅觉厌恶记忆相关的联想突触可塑性至关重要

• 发表时间: 2011
• 作者: Kosuke Yasuda;Yu Hayashi;Mika Tanaka;Shigeyoshi Itohara;上野耕平
• 通讯作者: 上野耕平

Exploring neural plasticity-related proteins by LC/MS/MS analysis in Drosophila mushroom body

通过 LC/MS/MS 分析果蝇蘑菇体探索神经可塑性相关蛋白

• 发表时间: 2012
• 作者: Yu Hayashi;Kazuya Sakai;Kosuke Yasuda;Julia Nguyen;Reiko Ando;Shigeyoshi Itohara;上野耕平
• 通讯作者: 上野耕平

Long-term enhancement of synaptic transmission between antennal lobe and mushroom body in cultured Drosophila brain

• DOI: 10.1113/jphysiol.2012.242909
• 发表时间: 2013-01-01
• 期刊: JOURNAL OF PHYSIOLOGY-LONDON
• 影响因子: 5.5
• 作者: Ueno, Kohei;Naganos, Shintaro;Saitoe, Minoru
• 通讯作者: Saitoe, Minoru