Imaging study of the physiological relationship between dopaminergic neurons and memory central

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The plastic change in the synaptic transmission is underlying learning and memory formation. Recent studies have suggested that dopamine is important for the plasticity, while the physiological mechanisms is unclear. In Drosophila, dopamine signaling is also required for olfactory aversive memory that is induced by odor and electrical shock. Previously, I have reported that simultaneous stimulation of odor and shock inputs induced plastic change in the mushroom body, olfactory memory center, in isolated brain via dopamine signaling. Here, I examined the relationship between dopamine signaling and neural plasticity in mushroom body, and found that dopamine release is occurred when mushroom body is activated by simultaneous inputs from odor and shock.