A study of the method of diagnosing/imaging brain tissue viability using light scattering

为了开发非侵入性的实时诊断技术来监测脑组织活性，例如在中风患者中，我们通过动物实验研究了基于光散射的光学方法的有效性。我们研究了与脑组织活力丧失相关的光散射变化的信号源，并揭示了光散射的时空变化与脑组织的可逆性之间的关系。我们还进行了梗死区周围去极化的光散射成像，这可能与梗死区的扩大有关。本研究结果不仅为卒中的诊断提供了新的思路，而且为卒中的病理生理学和新的治疗方法提供了新的思路。

For the development of non-invasive, real-time diagnostic technique for monitoring brain tissue viability such as in stroke patients, we investigated the validity of a light-scattering-based optical method by animal experiments. We examined signal sources of light-scattering change associated with loss of brain tissue viability, and revealed the relationship between spatiotemporal change in light scattering and reversibility of the brain tissue. We also performed light-scattering imaging of peri-infarct depolarization which can be associated with expansion of infarct area. The results will provide new insight into not only diagnosis but also pathophysiology and new therapeutic approach for the stroke.