Development of tumor immunotherapy based on the control of distribution and function of macrophages with DDS-type "Find-me" signals

众所周知，巨噬细胞是通过死细胞释放的“Find-me”信号来有效清除死细胞的。在本研究中，利用药物传递系统（DDS）和材料技术，设计和制备了能够同时包含巨噬细胞的吸引（“Find-me”信号）和激活药物并将其递送到肿瘤组织的纳米结构。此外，我们还对制备的纳米结构用于肿瘤免疫治疗的可能性和机制进行了评价。

It has been well recognized that dead cells are effectively eliminated by macrophages based on “Find-me” signals released from dead cells. In this study, nanostructures, which enable to simultaneously include attraction (“Find-me” signals) and activation drugs of macrophages and deliver to the tumor tissue, were designed and prepared by making use of drug delivery systems (DDS) and material technologies. In addition, we evaluated the possibility and mechanism of tumor immunotherapy with the nanostructures prepared.