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The effects of early exercise on brain damage and recovery after focal cerebral infarction in rats.

早期运动对局灶性脑梗死大鼠脑损伤及恢复的影响。

基本信息

批准号：
23700609
负责人：
MATSUDA Fumiyo
金额：
$ 2.83万
依托单位：
Kagoshima University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Young Scientists (B)
财政年份：
2011
资助国家：
日本
起止时间：
2011 至 2012
项目状态：
已结题

项目摘要

The purpose of this study was investigate that the effect of early exercise (this study used the treadmill exercise) after cerebral infarction in the rat. Next day after surgery, stroke rats were randomly assigned to two groups: treadmill-exercised group or non-exercised controls. After ischemia, the rats were received to run on a treadmill for 20 min once a day. All rats were observed the absence of motor coordination and neurological deficits after surgery. Over time motor coordination and neurological deficits improved more in the exercised group than in the non-exercised group. The cellular expression levels of MK were significantly increased in the peri-infarct area of the exercised rats. Therefore The purpose is to confirm the effect of MK gene knockout on cerebral infarction in mouse and the relation of MK with theregeneration. The ratios of infarct volume to cerebral hemisphere were not different between KO and wild type mice at 3 days and 7days. The expression of glial fibrially acidic protein (GFAP) was more and more expressed in periinfarct area after insult. GFAP staining areas in astrocytes (calculated as a ratio of stained areas to hemisphere)were significantly decreased in parietal lobe of KO mice compared with that in wild type mice at 3 days, however, it was not significantly different at 7 days. Since MK has a role as achemotaxis of microglias and macrophages, the Iba1 expression was studied with immunostaining, which showed no significant difference. The results were suggestive that in KO mice the expression of 機関番号：17701 研究種目：若手研究(B) 研究期間：2011 ～ 2012 課題番号：23700609 研究課題名（和文）脳血管障害後の早期運動療法介入が脳の損傷と回復に与える影響について研究課題名（英文） The effects of early exercise on brain damage and recovery after focal cerebral infarction in rats. 研究代表者松田史代（MATSUDA FUMIYO）鹿児島大学・医学部・助教研究者番号：70437953 GFAP was delayed compared with in wild type mice. MK participates in the development of the reactive astrocytes after cerebral infarction.

本研究旨在探讨大鼠脑梗塞后早期运动(本研究采用跑台运动)的效果。术后第二天，卒中大鼠被随机分为两组：跑步机运动组和非运动对照组。缺血后，大鼠在跑步机上跑20min，每天1次。所有大鼠术后均观察到运动协调功能缺失和神经功能缺失。随着时间的推移，运动组的运动协调性和神经功能障碍比非运动组改善得更多。运动组大鼠脑梗死区MK的细胞表达水平明显升高。因此，本研究的目的是证实MK基因敲除对小鼠脑梗塞的影响及其与再生的关系。3天和7天时，KO组和野生型小鼠脑梗塞体积与大脑半球的比值无明显差异。脑损伤后梗死灶周围区神经胶质纤维酸性蛋白(GFAP)表达增强。3d时KO组小鼠顶叶星形胶质细胞GFAP染色面积(染色面积与半球面积之比)较野生型小鼠显著减少，7d时差异无统计学意义。由于MK对小胶质细胞和巨噬细胞具有趋化作用，因此用免疫组织化学方法研究了Iba1的表达，结果显示两者无显著差异。结果提示，在KO小鼠中，機関番号：17701研究種目:若手研究(B)研究期間：17701~2012年課題番号：23700609研究課題名(和文)脳血管障害後の早期運動療法介入が脳の損傷と回復に与える影響について研究課題名(英文的表达可能是早期运动对大鼠局灶性脑梗塞后脑损伤和恢复的影响。研究代表者松田史代(Matsuda Fumiyo)鹿児島大学·医学部·助教研究者番号：70437953与野生型小鼠相比延迟。MK参与脑梗塞后反应性星形胶质细胞的发育。

项目成果

期刊论文数量（0）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

成長因子ミッドカイン（MK）の欠損がマウス骨格筋損傷病態に与える影響

生长因子中期因子（MK）缺乏对小鼠骨骼肌损伤病理的影响

DOI：
发表时间：
2012
期刊：
影响因子：
0
作者：
福田祐子;松田史代;榊間春利;吉田義弘;米和徳;三宅智;福田祐子;三尾直樹，神津玲，森本陽介，米倉剛，河野浩章，本村秀樹，前村浩二，江石清行;生友聖子
通讯作者：
生友聖子

Potential of edaravone for neuroprotection in neurologic diseases that do not involve cerebral infarction.

依达拉奉对不涉及脑梗塞的神经系统疾病具有神经保护作用的潜力。

DOI：
发表时间：
2011
期刊：
Experimental and Therapeutic Medicine
影响因子：
2.7
作者：
K. Kikuchi;K. Kawahara;H. Uchikado;N. Miyagi;T. Kuramoto;T. Miyagi;Y. Morimoto;Takashi Ito;S. Tancharoen;N. Miura;K. Takenouchi;Yoko Oyama;B. Shrestha;F. Matsuda;Y. Yoshida;Shinihiro Arimura;Kentaro Mera;K. Tada;Narimasa Yoshinaga;Ryuichi Maenosono;Yoshiko Ohno;T. Hashiguchi;I. Maruyama;M. Shigemori
通讯作者：
M. Shigemori

The effects of early low-intensity exercise on rat soleus after focal cerebral infarction in rats

早期低强度运动对大鼠局灶性脑梗死后比目鱼肌的影响

DOI：
发表时间：
2011
期刊：
影响因子：
0
作者：
Megumi Sakasegawa;Fumiyo Matsuda;Ai Irie;Keiko Ikeda;Harutoshi Sakakima;Kazunori Yone;Yoshihiro Yoshida
通讯作者：
Yoshihiro Yoshida

成長因子ミッドカイン(MK)の欠損がマウス骨格筋損傷病態に与える影響

生长因子中期因子（MK）缺乏对小鼠骨骼肌损伤病理的影响