Efficacy of body-weight supported treadmill exercise after spinal cord injury

在这项研究中，我们比较了脊髓损伤后早期和延迟干预跑步机训练对功能的影响，并对脊髓进行了组织学检查。脊髓损伤大鼠被分配到以下条件之一：控制，早期训练和延迟训练。早期训练组的步高和步长显著增加，而延迟训练组无显著改善。虽然训练量与训练效果之间存在显著的相关性，但早期训练组的功能改善与训练量无关。额外的组织学检查显示神经递质表达的变化，这可能有助于早期干预训练的积极作用。

In this study, we compare the functional effects of early and delayed intervention of treadmill training after spinal cord injury, and conduct a histological examination of the spinal cord. The spinal cord injured rats were assigned to one of the following conditions: control, early training, and delayed training. A significant increase in step height and step length was observed in the early-training group, while the delayed-training group showed no significant improvement. Although there was a significantcorrelation between the quantity of training and the effect of the training, the functional improvement in the early-training group was independent of the amount of training. The additional histological examination revealed the changes in the expression of neurotransmitters, which possibly contribute to the positive effect of early intervention of training.