Oxidative stress in polio survivors and the patients with post-polio syndrome

这项研究的目的是调查氧化应激是否是脊髓灰质炎后综合征(PPS)的病因。我们检测了27名脊髓灰质炎幸存者(平均年龄59.3岁)和13名健康对照(平均年龄58.0岁)的氧化应激标志物。与健康对照组相比，脊髓灰质炎幸存者的尿8-羟基脱氧鸟苷(8-OHdG)浓度显著升高。此外，与没有PPS的脊髓灰质炎幸存者相比，患有PPS的脊髓灰质炎幸存者的尿8-异前列腺素浓度显著增加。提示氧化应激可能是PPS的病因，8-异前列腺素可作为预测PPS的生物学指标。

The purpose of this study was to investigate whether oxidative stress is etiology of post-polio syndrome (PPS) . We examined the oxidative stress markers for 27 polio survivors (mean age, 59.3 years) and 13 healthy controls (mean age, 58.0 years). Urinary 8-hydroxydeoxyguanosine (8-OHdG) concentrations were significantly increased with polio survivors as compared to healthy controls. Moreover, urinary 8-isoprostane concentrations were significantly increased with polio survivors with PPS as compared to polio survivors without PPS. These results indicate that the oxidative stress may be etiology of PPS and suggest that 8-isoprostane may provide a biological marker for predicting PPS.