Establishment of the effective Nutrition Guidance for obese Patients based on Nutritional Intake and levels of Adipocytokine Levels

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1. EPA treatment significantly increased serum adiponectin and IL-10 expression in monocytes、and improved cardiovascular risk factors including CAVI. In addition, the changes of EPA/AA ratio after EPA treatment had a stronger association with the improvement of CVD risk factors, relative to the ratio of other serum fatty acids. Furthermore, in vitro study, we showed that EPA exert the favorable effect of the quality of monocyte function through the activation of PPARγ.2. Treatment with a natural S-equol supplement, one of soy isoflavones, had a significant effect on improving fasting plasma glucose, LDL-C and CAVI, an index of arterial index.Therefore, this study will enable to provide a new dietary guideline based on the new functionality of each nutrient and may lead to the development of new functional foods for the prevention of CVD.