Association of genetic polymorphisms in hypertension related genes with an increased risk of cardiovascular disease in hypertensive patients

血压(BP)的变化，特别是睡眠中的非下降模式，已知会增加高血压患者发生心血管事件的风险。在本研究中，我们研究了日本高血压患者高血压相关基因185个单核苷酸多态性(SNPs)与血压昼夜变化的关系。我们发现ACE2、ECE2、SCNN1A、SLC12A3、MOP4、PER2和PER3基因的SNPs与高血压病患者的血压无明显相关。我们还发现EDNRA和NCX1基因的SNPs与高血压患者慢性肾脏疾病并发症的患病率显著相关。VWF基因SNP与高血压患者颈动脉内膜中层厚度相关。综上所述，ACE2、ECE2、SCNN1A、SLC12A3、MOP4、PER2、PER3、EDNRA、NCX1和VWF基因的遗传多态可能导致日本高血压患者发生心血管事件的风险增加。

Blood pressure (BP) variations, especially non-dipping patterns during sleep, are known to increase cardiovascular event risk in hypertensive patients. In this study, we examined the relationship between 185 single nucleotide polymorphisms (SNPs) in hypertension related genes and circadian variation of BP in Japanese hypertensives. We found that the SNPs in ACE2, ECE2, SCNN1A, SLC12A3, MOP4, PER2 and PER3 genes were significantly associated with the non-dipping pattern of BP in essential hypertensive patients. We also found the significant association between the SNPs in EDNRA and NCX1 genes and the prevalence of chronic kidney disease complication in hypertensives. The SNP in VWF gene was associated with the carotid intima-media thickness in hypertensives. Taken together, our results revealed that the genetic polymorphisms in ACE2, ECE2, SCNN1A, SLC12A3, MOP4, PER2, PER3, EDNRA, NCX1 and VWF genes could cause an increased risk of cardiovascular event in Japanese hypertensives.