Decreased or increased ganglioside converting enzymes by daily exercise in adult mouse model and applied for Alzheimer's disease therapy

通过成年小鼠模型的日常运动减少或增加神经节苷脂转换酶并应用于阿尔茨海默病治疗

• 批准号: 23700829
• 负责人: HAYASHI Yuichi
• 金额: $ 2.41万
• 依托单位: Gifu University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011 至 2013
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23700829/
• 关键词: 運動療法; St8Sia1; ガングリオシド変換酵素種; トレッドミル運動; アルツハイマー病; 認知症

St8Sia1 is one of the important protein concerning about progression of Alzheimer's disease experimental mouse model. The mRNA St8sia1 is down regulated by daily exercise in adult mice. The St8sia1 protein is slightly down regulated by daily exercise in adult mice. This result may be one the mechanisms concerning about anti- progression of Alzheimer's disease with daily exercise patients.

St8Sia1是与阿尔茨海默病实验小鼠模型进展有关的重要蛋白质之一。成年小鼠的mRNA St8 sia1因日常运动而下调。St8sia1蛋白在成年小鼠的日常运动中略有下调。这一结果可能是日常运动对阿尔茨海默病患者抗进展的机制之一.

项目成果

Late-onset patients with sporadic amyotrophic lateral sclerosis in Japan have a higher progression rate of ALSFRS-R at time of diagnosis

日本迟发性散发性肌萎缩侧索硬化症患者在诊断时 ALSFRS-R 进展率较高

• 发表时间: 2012
• 期刊: Internal Med.
• 作者: Tanaka Y;Yoshikura N;Harada N;Yamada M;Koumura A;Sakurai T;Hayashi Y;Kimura A;Hozumi I;Inuzuka T
• 通讯作者: Inuzuka T

Multi-professional medication review using computerized medical records helps reduce the numbers of drugs for elderly in-patients.

使用计算机病历进行多专业用药审查有助于减少老年住院患者的用药数量。

• 发表时间: 2013
• 作者: Hayashi Y;Yamada M;Yoshikura N;Harada N;Koumura A;Kimura A;Inuzuka T.
• 通讯作者: Inuzuka T.

Is there delayed gastric emptying in patients with multiple system atrophy? An analysis using the 13C-acetate breath test

• DOI: 10.1007/s00415-011-6372-7
• 发表时间: 2012-07-01
• 期刊: JOURNAL OF NEUROLOGY
• 影响因子: 6
• 作者: Tanaka, Yuji;Kato, Tomohiro;Inuzuka, Takashi
• 通讯作者: Inuzuka, Takashi

Corticosteroid therapy in a patient with cerebral amyloid angiopathy-related inflammation.

• DOI: 10.1186/1742-2094-10-39
• 发表时间: 2013-03-16
• 期刊: Journal of neuroinflammation
• 影响因子: 9.3
• 作者: Kimura A;Sakurai T;Yoshikura N;Hayashi Y;Takemura M;Takahashi H;Inuzuka T
• 通讯作者: Inuzuka T

Hayashi Y, Suwa T, Inuzuka T: Intracranial calcification in a patient with HDR syndrome and a GATA3 mutation.

Hayashi Y、Suwa T、Inuzuka T：HDR 综合征和 GATA3 突变患者的颅内钙化。

• 发表时间: 2013
• 期刊: Internal Medicine
• 影响因子: 1.2
• 作者: Hayashi Y;Suwa T;Inuzuka T
• 通讯作者: Inuzuka T