A study of molecular mechanisms of alzheimer's disease caused by endoplasmic reticulum stress.

肥胖和2型糖尿病等代谢性疾病是阿尔茨海默病的危险因素。一些研究表明，内质网（ER）应激有助于肥胖和糖尿病的发病机制。然而，Aβ产生的机制仍不清楚。我研究了ER应激是否会增强Aβ的产生，以及来自天然提取物的IRE 1激活化合物槲皮素的作用。结果发现：（1）内质网应激可通过ATF 4促进PS1的表达和Aβ的分泌;（2）槲皮素可抑制内质网应激诱导的ATF 4的表达和A β的分泌。

Metabolic diseases such as obesity and type-2 diabetes are risk factor for Alzheimer’s disease. Several studies indicate that endoplasmic reticulum (ER) stress contributes to the pathogenesis of obesity and diabetes. However, the mechanism to underlie Aβ production remains to be unknown. I investigated whether ER stress enhances Aβ production, and the effect of an IRE1-activating compound from natural extracts, quercetin. I found that(1) the PS1 expression and Aβ secretion were increased by ER stress through the ATF4(2) quercetin inhibits ER stress-induced ATF4 expression and Aβ secretion.