Role of nutrients against intestinal functions recovery under non-enteral nutrition state

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We analyzed underlying mechanism of villus atrophy by non-influx of nutrient, and investigated whether re-administration of nutrient recovers intestinal functions using nutrient non-influx model of rats. Our data suggested that inactivation of mTOR pathway and downregulation of cell cycle related genes such as cyclins are associated with villus atrophy in non-influx model animals. In addition, we demonstrated that almost genes related to digestion and absorption of nutrients significantly increased by re-administration of nutrient. Interestingly, we revealed that there was a different effect between each nutrient category such as carbohydrates, lipids and amino acids and further between each nutrient quality such as glucose, fructose, medium-chain triacylglycerol, long-chain triacylglycerol, glutamine and arginine.