Common bean extract intake improves lipid/carbohydratemetabolism disorder

摄入普通豆提取物可改善脂质/碳水化合物代谢紊乱

• 批准号: 23700922
• 负责人: SEO Makoto
• 金额: $ 1.75万
• 依托单位: Saitama Medical University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011 至 2012
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23700922/
• 关键词: いんげん豆; 脂肪肝; 脂質代謝; 糖質代謝; アディポサイトカイン; 高脂肪食; シグナル伝達; 脂肪滴蓄積

High fat-induced body weight gain, liver and adipose tissue weight gain were suppressed by ingestion of common bean extract, and serum fat/carbohydrate parameters and adipocytokines concentration were also improved near by normal mice. Moreover, lipid droplet accumulation in the liver was reduced by ingestion of common bean extract. It is suggested that the mechanisms of these improvement effects may be regulated the gene expression of lipid-carbohydrate metabolism pathways and also be regulated the activation of the multiple transcriptional factors and signaling factors.

高脂肪诱导的体重增加，肝脏和脂肪组织的重量增加被抑制摄入菜豆提取物，血清脂肪/碳水化合物参数和脂肪细胞因子浓度也得到改善，接近正常小鼠。此外，通过摄入普通豆类提取物，肝脏中的脂滴积累减少。这些改善作用的机制可能是通过调节脂糖代谢途径的基因表达，以及多种转录因子和信号因子的激活来调节。