Molecular mechanism for collective invasion of cancer cell groups

我们发现，整合素β1的表达上调，在领先的细胞相比，尾随细胞。整合素β1表达的增加对于作为一个群体移动的细胞的有效迁移至关重要。RET指蛋白（RFP）和肌红蛋白相关转录因子B（MRTF-B）是两种转录调节因子，它们在细胞间粘附功能丧失的情况下形成复合物，激活Rho GT3，并通过抑制整合素β1靶向的microRNA-124上调整合素β1的表达。我们的研究结果揭示了LC和FC异质性的分子机制。

We revealed that expression of integrin β1 is up-regulated in leading cells compared to trailing cells. Increase of integrin β1 expression is crucial for effective migration in cells moving as a group. Two transcriptional regulators, RET Finger Protein (RFP) and Myocardin Related Transcription Factor-B (MRTF-B), form complex responding to the partial loss of cell-cell adhesion in leading cells, which activate Rho GTPase, and up-regulates the integrin β1 expression through the repression of integrin β1-targetting microRNA-124 in LC. Our findings revealed the molecular mechanism that defines heterogenous properties of LC and FC.